Does finasteride help hair loss ?" – a typical question people with male pattern baldness might find themselves asking. "We're trying Buying clomid online canada to do a clinical trial of 1,000 people to see how long they live after a treatment with finasteride," says Robert Vanacore, M.D., lead author of the published study. study was today in PLOS One. "A treatment is a treatment," says Vanacore, of Northwestern University Medical School, who Where can i buy azithromycin or doxycycline also worked at the University of Toronto. "If it had been shown that this was an effective treatment, no doubt patients would have demanded it for themselves," he says. To answer this question, researchers will examine the lifespans of 1,000 eligible patients who have a new hairline and want to keep their hair because of male pattern baldness. Men with baldness can have receding hairlines, which be as much 2 inches in length. The condition is most prevalent in men over 50, with most affected younger men. As the body slowly produces new hair follicles to replace the that has been lost, hair falls out in clumps called "halo hairs." These bald patches can extend over 10 or 15 years. Finasteride has been recommended by dermatologists for halting the formation of these halo hairs and promoting hair growth. However, "until recently" it wasn't clear which was the actual source of hair thinning. Finasteride acts on a protein called 5-alpha reductase, which is found in hair follicles (called follicles) and can inhibit the formation of new hair follicles, says Mark Yager, M.D., another lead author. In their new study, "we show we can block this by blocking the interaction between 5-alpha reductase and the proteins that generate halo hairs are the actual source of male pattern baldness," says Yager. This result is what scientists need to show a treatment actually works to halt the thinning and prevent hair loss, adds Vanacore. Men with male pattern baldness who have had the treatment for more than 12 months will receive up to 900 milligrams of finasteride every two weeks with side effects monitored throughout their treatment. In the trial, more than 250 participants will be randomly assigned to receive the drug, called Propecia, or to receive a placebo once. Researchers will look at hair growth patterns in the samples of study group. If finasteride treatment appears to halt hair loss in the samples, researchers plan to repeat the study. If it does not, they would do a "double blind" trial where participants would receive the drug but, no one would know whether the participants had received drug. "I wouldn't want my girlfriend not to be happy if I didn't treat myself to this new treatment because I would not want to be able say her," says Vanacore. "This treatment will be given to the 1,000 people, and then we'll see how things turn out if we repeat the study. it works, we want to see if the hair quality is better or if some of them continue to lose hair." The study is being conducted under FDA guidelines. Results of the study will help researchers develop a drug that does not interact with the 5-alpha reductase protein and is a good alternative to the finasteride drugs. This medication, called Dutasteride, is currently in clinical trials for treatment of benign prostatic hyperplasia and uterine fibroids. To read the study, visit PLOS ONE. (Photo from Erika Rosenbaum's finasteride temple hair loss Photostream on flickr. See other related posts by Erika Rosenbaum about balding and)

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